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Sep 13, 2022

What does the body of evidence say on the topic of Botox injections? Plus: we address the confusion over bivalent COVID-19 booster shots, and we look at a trial of magic mushrooms for alcohol use disorder!


Block 1:

(3:00) Botox: what it is and what botulism does to you


Block 2:

(9:00) Botox: how Botox works on wrinkles, a comparison between formulations, what can go wrong, why repeated injections are needed, and the non-cosmetic uses of the botulinum toxin


Block 3:

(23:08) Bivalent booster vaccines and the reactive, libertarian public health response


Block 4:

(36:01) Magic mushrooms for alcohol use disorder



* Jingle by Jillian Correia of Roctavio Canada

* Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.

* Assistant researcher: Nicholas Koziris


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1) Our episode on sunscreen:


2) The cosmetic benefit of botulinum toxin:


3) Differences between formulations:


4) The FDA’s black box warning for Botox:


5) Antibody formation after Botox:


6) Cochrane review of Botox for migraine:


7) Cochrane review of Botox for cervical dystonia:


8) Botox for urgency urinary incontinence:,improvements%20in%20quality%20of%20life


9) New clinical trial of psilocybin-assisted psychotherapy for alcohol use disorder:



Music Credits:


The following music was used for this media project:

Music: Main Theme (The Grand Score) by Alexander Nakarada

Free download:

License (CC BY 4.0):

Artist website: